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An Overview of Metformin 1000 mg Tablets: Benefits, Side Effects, and Dosage

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Metformin, often referred to as a longevity drug, is know to offer numerous benefits such as increased insulin sensitivity and activation of mTOR pathways. However, some individuals may experience digestive system intolerance to the medication, leading to gut dysbiosis symptoms and hence an ineffective diabetes management. In such cases, alternative natural options like Berberine can be considered. It is important to understand potential nutrient absorption issues and deficiencies before starting Metformin and also whether being dependant on medicine for a long period is suitable for the body and its functioning.

The Benefits of Taking Metformin

Metformin has gained recognition as an effective medication for diabetes management. It improves insulin sensitivity, which is known to help regulate blood sugar levels. Additionally, metformin activates the mTOR pathways, which have been associated with increased lifespan and improved health. It is considered a valuable drug for diabetes control and offers potential benefits beyond glycemic control, such as reducing the risk of certain cancers and cardiovascular diseases. Metformin has also shown promise in managing polycystic ovary syndrome (PCOS) and aiding weight loss efforts in some individuals. However, looking at Metformin through this angle alone is not enough for it to be considered safe and assured.

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Considerations and Alternatives

Many individuals can experience side effects of metformin related to gastrointestinal, such as bloating, gas, and indigestion. In such cases, Berberine, a natural supplement, can be considered as an alternative. Berberine has shown comparable results to metformin in lowering haemoglobin A1c levels and offers additional health benefits. It is known to be better tolerated by many individuals, making it a suitable option for those who experience digestive discomfort with metformin.

Potential Nutrient Absorption Issues

Metformin is known to hinder the absorption of certain nutrients, particularly vitamin B12, which can lead to deficiencies in these parameters. It is advisable for individuals who are deficient or borderline in these nutrients to undergo testing before starting metformin treatment. Regular monitoring of nutrient levels can help ensure that any deficiencies are addressed appropriately, either through supplementation or dietary adjustments.

Proper Dosing and Maximum Limits

Metformin dosing should be determined by a healthcare professional based on individual needs and response to treatment. The maximum recommended daily dose of metformin varies depending on the formulation and strength prescribed. It is essential to follow the prescribed dosage instructions and consult with a healthcare provider for proper guidance.


While Metformin offers significant benefits for diabetes management and beyond. However, individual tolerance and potential nutrient absorption issues should be considered. Exploring alternative options like Berberine can be beneficial for those who experience digestive discomfort with metformin. Regular monitoring of nutrient levels and proper dosing guidance from healthcare professionals are crucial for optimising the use of metformin in diabetes treatment. Also it is important to understand that relying solely on medications to manage or reverse diabetes is not an optimal solution, since research is showing that being dependant on drugs can actually prove to be counter-productive. Hence one must take a very conscious and aware decision on being dependant on drugs for diabetes and other chronic disease management.

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