What happens if sugar level is high?

High sugar level over a period of time cause glucotoxicity. It causes glycation of proteins and minerals affecting their function. Advanced glycosylated End (AGE) products cause accelerated aging. It often exacerbates microvascular complications like neuropathy, retinopathy & nephropathy probably due to the Sorbitol pathway. Glucotoxicity can cause increased conversion of excess glucose into fructose by polyol pathway increasing DNL (De novo Lipogenesis) in the liver, worsening Fatty liver and further increasing insulin resistance. It can increase the risk of heart attacks and strokes.